| 张成,何冠睿,刘小宇.雷公藤福定五环骨架的合成[J].井冈山大学自然版,2025,46(4):15-23 |
| 雷公藤福定五环骨架的合成 |
| SYNTHESIS OF THE PENTACYCLIC CORE OF TRIPTERIFORDIN |
| 投稿时间：2025-01-02 修订日期：2025-03-21 |
| DOI：10.3969/j.issn.1674-8085.2025.04.003 |
| 中文关键词: 五环二萜 雷公藤福定 Heck反应 自由基环化 |
| 英文关键词: pentacyclic diterpene tripterifordin heck reaction radical cyclization |
| 基金项目:国家自然科学基金项目(22071161)；四川省科技计划资助项目(2024ZYD0100) |
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| 中文摘要: |
| 本实验研究了二萜类化合物雷公藤福定五环骨架的合成。雷公藤福定是从雷公藤中分离而得到的，其具有显著的抗HIV活性。该化合物结构复杂，包含五环母核以及七个手性中心，这给其合成带来了巨大挑战。本研究通过Suzuki偶联、Heck反应、Birch还原和自由基环化等关键步骤，经过16步反应完成了目标五环二萜雷公藤福定核心骨架的构筑。 |
| 英文摘要: |
| The synthesis of the pentacyclic core of tripterifordin, a diterpene isolated from Tripterygium wilfordii, was reported. Notably, this compound has a complex structure, featuring a pentacyclic core and seven chiral centers, which poses considerable challenges for its synthesis. In this study, the core skeleton of tripterifordin was successfully constructed through a 16-step process involving Suzuki coupling, Heck coupling, Birch reduction, and radical cyclization. |
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