| 胡文杰,俞静怡,罗辉.芳姜黄酮衍生物的设计合成及其抑菌活性研究[J].井冈山大学自然版,2024,45(4):50-55 |
| 芳姜黄酮衍生物的设计合成及其抑菌活性研究 |
| DESIGN, SYNTHESIS AND ANTIFUNGAL ACTIVITY OF AR-TURMERONE DERIVATIVES |
| 投稿时间：2024-04-26 修订日期：2024-06-06 |
| DOI：10.3969/j.issn.1674-8085.2024.04.008 |
| 中文关键词: 芳姜黄酮衍生物 设计 合成 抑菌 |
| 英文关键词: ar-turmerone derivatives design synthesis antifungal |
| 基金项目:国家自然科学基金项目(32160089） |
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| 中文摘要: |
| 为了寻找具有较高活性的芳姜黄酮类衍生物，根据芳姜黄酮的结构特点，对其进行了针对性的修饰，并利用1H NMR和13C NMR等技术将其结构进行表征；同时采用梯度稀释方法制备不同浓度的化合物溶液，将制备好的溶液进行平板涂布，确定化合物的最低抑菌浓度。实验结果表明：设计合成的7个（A ~ G）新型衍生物对尖孢镰刀菌均表现出了不同程度的抑制效果。其中，化合物E、F的抑菌效果最为显著；化合物B、C、D、G的抑菌活性较强；而化合物A的抑菌效果相对较弱。本研究结果可以为未来在芳姜黄酮类药物研发领域提供参考作用。 |
| 英文摘要: |
| The aim of this paper is to try to find high biological ar-turmerone derivatives. According to the structural characteristics of ar-turmerone, it was modified and its structure was characterized by 1H NMR and 13C NMR; At the same time, the compound solutions of different concentrations were prepared by gradient dilution method, and the prepared solutions were coated on a plate to determine the minimum antifungal concentration of the compound. The results showed that the seven new derivatives (A - G) designed and synthesized showed different degrees of inhibitory effects on Fusarium oxysporum. Among them, the antifungal effects of compounds E and F were the most significant; compounds B, C, D and G had strong antifungal activity; The antifungal effect of compound A was relatively weak. This study can provide certain reference basis for future research and development in the field of ar-turmerone drugs. |
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