| 胡启龙,熊小峰.甲基硫醚基团的官能化研究（特约稿）[J].井冈山大学自然版,2023,44(3):19-23 |
| 甲基硫醚基团的官能化研究（特约稿） |
| Functionalization of methylthio derivativeS |
| 投稿时间：2023-02-01 修订日期：2023-03-20 |
| DOI：10.3969/j.issn.1674-8085.2023.03.003 |
| 中文关键词: 甲基硫醚 溴代物 烷基化 硫醚 |
| 英文关键词: methylthio ether bromide alkylation thioether |
| 基金项目:国家自然科学基金项目(81602972) |
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| 摘要点击次数: 444 |
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| 中文摘要: |
| 本研究以甲基硫醚与溴代烷为原料，以生成热力学更稳定的硫醚为驱动力，在相对温和的条件下通过一锅法直接制备新的硫醚衍生物。该方法避免了使用过渡金属，额外的添加剂以及严格的无水无氧条件，而且底物范围广，平均收率大于70%。通过本研究发展的硫醚官能化方法，成功对一系列的芳香/脂肪烷基甲基硫醚衍生物实现了进一步烷基化，包括非天然甲硫氨酸单体合成子的制备。 |
| 英文摘要: |
| An efficient method for one-pot preparing thioether had been developed by employing methylthio derivative and bromoalkane, which was driven by the formation of a more thermodynamic stable thioether. This approach was transition-metal-free and could be conducted under air. Moreover, this reaction was with broad substrate scope and high yield (> 70%). A series of aromatic/aliphatic alkyl methyl thioether derivatives could be alkylated successfully, including the preparation of an unnatural methionine synthon. |
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