| 范威.吲哚骨架4位的乙酯基化研究[J].井冈山大学自然版,2022,43(1):38-41 |
| 吲哚骨架4位的乙酯基化研究 |
| ETHYLATION OF 4-POSITION OF INDOLE SKELETON |
| 投稿时间：2021-08-22 修订日期：2021-10-02 |
| DOI：10.3969/j.issn.1674-8085.2022.01.006 |
| 中文关键词: 苊醌 乙酸酐 4-乙酯基吲哚衍生物 |
| 英文关键词: acenaphthoquinone acid anhydride 4-ethyl ester indoles |
| 基金项目:国家自然科学基金项目（21272095）；安徽省教育厅科学研究重点项目（KJ2020A1003） |
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| 中文摘要: |
| 4位官能化的吲哚衍生物，可用作流感的抗病毒治疗、神经毒素、抗菌剂。因此，吲哚骨架4位的修饰研究值得探讨。从N-芳基环己-2-烯酮、苊醌、乙酸酐出发，120℃微波辐射条件下，一步合成了4-乙酯基吲哚衍生物，补充了吲哚骨架4位的修饰。其结构也得到了单晶的证实。反应机理涉及分子内环化、脱水、互变异构、酯化等诸多步骤。 |
| 英文摘要: |
| The 4-position functionalized indoles can be used as antiviral therapy for influenza, neurotoxins and antibacterial agents. Therefore, the modification study on the 4-position of indole skeleton is worth discussing. Starting from N-arylcyclohex-2-enone, acenaphthoquinone, and acetic anhydride, under the condition of microwave irradiation at 120℃, 4-ethyl ester indoles were synthesized in one step and supplemented the modification of the 4-position of indole skeleton. The structure is confirmed by single crystal. The reaction mechanism involves steps such as intramolecular cyclization, dehydration, tautomerism and esterification. |
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