| 周秋贵,张维军,曾红,陈婷.葛根素脉冲胶囊的制备及影响释药时滞的因素研究[J].井冈山大学自然版,2021,42(6):97-100 |
| 葛根素脉冲胶囊的制备及影响释药时滞的因素研究 |
| PREPARATION OF PUERARIN PULSE CAPSULES AND THE FACTORS AFFECTING DRUG RELEASE DELAY |
| 投稿时间：2020-11-26 修订日期：2021-01-19 |
| DOI：10.3669/j.issn.1674-8085.2021.06.018 |
| 中文关键词: 葛根素 脉冲胶囊 释药时滞 |
| 英文关键词: puerarin pulse capsule drug release delay |
| 基金项目:吉安市科技支撑项目(吉市科计字[2020]20号8) |
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| 中文摘要: |
| 目的 制备葛根素脉冲胶囊，并对影响释药时滞的因素进行研究。方法 采用灌注法制备不溶性囊壳体，滴制法制备葛根素滴丸，湿法制粒压片法压制柱塞片，将其组装成柱塞型胶囊，考察影响释药时滞的各种因素，评价其体外释药行为。结果 柱塞片的乳糖与HPMCK15M质量比为30%，片重为80 mg，硬度为65 N，Φ为6.0 mm，可满足葛根素脉冲胶囊释药时滞5 h的设计要求。结论 通过调节柱塞片中乳糖-HPMCK15M质量比、片重、硬度及片茎等因素可获得具有适当释药时滞的脉冲胶囊。 |
| 英文摘要: |
| Objective:To prepare puerarin pulse capsules and study the factors that affect the release delay. Methods:The insoluble capsules were prepared by infusion method, puerarin dripping pills were prepared by dripping method, plunger tablets were compressed by wet granulation and tableting method, and assembled into plunger-type capsules. Various factors affecting drug release time lag were investigated and evaluated. Results: The mass ratio of lactose to HPMCK15M of the plunger tablet was 30%, the tablet weight was 80 mg, the hardness was 65 N, and the Φ was 6.0 mm, which could meet the design requirements of the puerarin pulse capsule with a drug release delay of 5 hours. Conclusion:By adjusting the prescription composition and tablet weight of plunger tablets, pulsed capsules with appropriate release time lag can be obtained. |
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