| 黄雅丽,林志彬,郭璐倩.大豆素固体分散体的制备及溶解性能研究[J].井冈山大学自然版,2021,42(1):20-25 |
| 大豆素固体分散体的制备及溶解性能研究 |
| STUDY ON PREPARATION AND DISSOLUTION PROPERTIES OF SOLID DISPERSIONS OF DAIDZEIN |
| 投稿时间：2020-11-12 修订日期：2020-12-12 |
| DOI：10.3969/j.issn.1674-8085.2021.01.004 |
| 中文关键词: 大豆素 PVP 固体分散体 盐酸水苏碱 溶解度 |
| 英文关键词: daidzein PVP solid dispersion stachydrine hydrochloride solubility |
| 基金项目:闽江学院校长基金项目（103952018140，103952018139） |
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| 中文摘要: |
| 以PVP作为载体，利用旋转蒸发法制备了大豆素固体分散体，通过XRD对固体分散体进行表征，采用紫外-可见分光光度计考察了固体分散体的溶解度。研究结果表明，大豆素与PVP形成固体分散体后，以无定型的形式高度分散在PVP载体中，大豆素在水中的溶解度显著提高；当大豆素与PVP的质量比为1：1时，固体分散体中大豆素在水中溶解度与大豆素的相比提高了32倍；加入盐酸水苏碱可以和大豆素、PVP形成三元固体分散体，且溶解度进一步提高，是大豆素的57倍，有利于改善大豆素的生物利用度。 |
| 英文摘要: |
| The solid dispersion of daidzein was prepared with PVP as the carrier by rotating evaporation method in this paper. The solid dispersion was characterized by XRD. The solubility of solid dispersion was investigated by UV-Vis spectrophotometer. The results showed that the solubility of daidzein in water was significantly increased when daidzein and PVP formed solid dispersion, and daidzein was highly dispersed in PVP carrier in an amorphous form. When the mass ratio of daidzein to PVP was 1:1, the solubility of solid dispersion in water was 32 times higher than that of daidzein. The ternary solid dispersion could be formed with daidzein and PVP by adding stachydrine hydrochloride, and the solubility of ternary solid dispersion was 57 times higher than that of daidzein, which was beneficial to improve the bioavailability of daidzein. |
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