| 匡仁云,郭瑾,谢宝星.3-(4-氟-苯基)-5-异丙基-2-苯基-吡咯-1-羧酸苯基酰胺的合成[J].井冈山大学自然版,2020,41(6):15-17 |
| 3-(4-氟-苯基)-5-异丙基-2-苯基-吡咯-1-羧酸苯基酰胺的合成 |
| SYNTHESIS OF 3-(4-FLUORO-PHENYL)-5-ISOPROPYL-2PHENYL -PYRROLE-1-CARBOXYLICACID PHENYLAMIDE |
| 投稿时间：2020-07-11 修订日期：2020-09-16 |
| DOI：10.3969/j.issn.1674-8085.2020.06.004 |
| 中文关键词: 羟醛缩合 吡咯衍生物 一锅法 合成 |
| 英文关键词: aldol reaction pyrrole derivative one-pot reaction synthesis |
| 基金项目:国家自然科学基金项目(21563015) |
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| 中文摘要: |
| 在强碱催化下,甲基异丙酮和4-氟苯甲醛通过羟醛缩合反应得到α,β-不饱和酮2,然后与苯甲醛生成1,4-二酮化合物,将其与醋酸铵在醋酸催化下一锅法得到吡咯化合物,最后在叔丁基锂强碱作用下,与苯基异氰酸酯反应得到目标产物吡咯羧酸苯基酰胺类化合物。 |
| 英文摘要: |
| α,β-unsaturated ketone is synthesized by aldol reaction of 4-fluorobenzaldehyde and methyl isopropyl ketone in presence of 15% KOH solution, then it reacts with benzaldehyde again for generating 1, 4-diketones compound, which reacts with NH4OAc under AcOH catalysis by one-pot synthesis and pyrrole compound is obtained. And finally, under the catalytic action of a strong base of tert-butyllithium, pyrrole compound react with isocyanato-benzene for the target product of phenylamide compounds of pyrrolidine carboxylate. |
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