| 王晓燕,梁生林.叶下花水煎剂抗炎镇痛作用的初探[J].井冈山大学自然版,2019,40(5):82-85 |
| 叶下花水煎剂抗炎镇痛作用的初探 |
| PRELIMINARY STUDY ON THE ANTI-INFLAMMATORT AND ANALGESIC EFFECTS OF AINSLIAEA PERTYOIDES DECOCTION |
| 投稿时间：2019-01-12 修订日期：2019-03-06 |
| DOI：10.3969/j.issn.1674-8085.2019.05.016 |
| 中文关键词: 叶下花 水煎剂 抗炎 镇痛 初探 |
| 英文关键词: Ainsliaea pertyoides decoction mice anti-inflammatory analgesia primary investigation |
| 基金项目:国家科技支撑计划项目子课题项目（2012BAC11B02-6） |
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| 中文摘要: |
| 目的 初步探讨叶下花水煎剂的抗炎镇痛作用。方法 采用二甲苯致小鼠耳肿胀炎症模型，观察叶下花水煎剂灌胃给药对急性炎症的作用。采用热板法和醋酸扭体法致痛，观察叶下花水煎剂灌胃给药的镇痛作用。结果 与模型组相比，叶下花水煎剂高、中、低剂量（6.0、3.0、1.5 g生药/kg）组对二甲苯所致小鼠耳肿胀具显著抑制作用（P<0.01）。叶下花水煎剂高、中、低剂量（6.0、3.0、1.5 g生药/kg）组给药后明显延长热板所致小鼠的痛阈值，与模型组和自身给药前比较差异极显著（P<0.01）；叶下花水煎剂高、中、低剂量（6.0、3.0、1.5 g生药/kg）组明显减少醋酸所致小鼠扭体反应次数，与模型组比较差异极显著（P<0.01）。结论 叶下花水煎剂灌胃给药均具有抗炎、镇痛作用。 |
| 英文摘要: |
| Objective:To investigate the anti-inflammatory and analgesic effects of Ainsliaea pertyoides decoction in mice. Methods:The models of mouse ear swelling caused by xylene and the models of mouse pain caused by hot plate and acetic acid were used to observe the anti-inflammatory effects and the analgesic effects of A. pertyoides decoction respectively. Results:Compared with the model group, high, medium and low doses of A. pertyoides decoction could significantly inhibit ear swelling in mice (P<0.01). Moreover, the pain threshold with hot plate method was significantly prolonged (P<0.01) compared with the model group and the data before the drugs administration of high, medium and low doses of A. pertyoides decoction. And the writhing number was significantly reduced (P<0.01) when contrasted to the model group after decoction administration. Conclusion:The results showed A. pertyoides decoction possesses the anti-inflammatory and analgesic effects. |
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