魏江存,秦祖杰,谢臻,陈勇,潘真真,邱美雁,张昕,阙祖亮.泻心汤不同剂量配伍的抗炎作用比较研究[J].井冈山大学自然版,2019,40(3):97-101 |
泻心汤不同剂量配伍的抗炎作用比较研究 |
COMPARATIVE STUDY OF XIEXIN DECOCTION WITH DIFFERENT-DOSE HERBS ON ANTI-INFLAMMATORY EFFECTS |
投稿时间:2019-01-02 修订日期:2019-03-27 |
DOI:10.3969/j.issn.1674-8085.2019.03.018 |
中文关键词: 泻心汤 剂量配伍 抗炎 |
英文关键词: Xiexin Decoction dose compatibility anti-inflammatory |
基金项目:国家自然科学基金项目(81360524,81660701);广西自然科学基金项目(2016GXNSFAA380148,2014GXNSFAA118208);广西中医药大学2018年广西一流学科建设项目重点课题(2018XK060);千金藤啶碱成分药材资源的筛选与开发(H14002);广西中药药效研究重点实验室(17-259-20);广西高校中药提取纯化与质量分析重点实验室(桂教科研[2014]6号);国家中医药管理局科研三级实验室中(壮)药化学与质量分析实验室(国中医药发2009[21]号) |
作者 | 单位 | 魏江存 | 广西国际壮医医院壮瑶药研发中心, 广西, 南宁 530201 广西中医药大学科学实验中心, 广西, 南宁 530200 | 秦祖杰 | 广西国际壮医医院壮瑶药研发中心, 广西, 南宁 530201 | 谢臻 | 广西中医药大学科学实验中心, 广西, 南宁 530200 | 陈勇 | 广西中医药大学科学实验中心, 广西, 南宁 530200 | 潘真真 | 广西中医药大学科学实验中心, 广西, 南宁 530200 | 邱美雁 | 广西国际壮医医院壮瑶药研发中心, 广西, 南宁 530201 | 张昕 | 广西中医药大学科学实验中心, 广西, 南宁 530200 | 阙祖亮 | 广西中医药大学科学实验中心, 广西, 南宁 530200 |
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中文摘要: |
目的 不同剂量配伍时泻心汤的抗炎作用的对比分析,其抗炎作用有何影响。方法 采用角叉菜胶导致小鼠炎症模型,经口灌胃小鼠不同剂量配伍的泻心汤水提液,连续灌胃给药5 d后,测定足肿胀度;试验测定丙二醛(MDA)含量和一氧化氮(NO)含量,查看其抗炎作用的活性。结果 对比模型炎症对照组,生理盐水组、地塞米松组及各个剂量配伍组的足肿胀度均比模型对照组低,差异有统计学意义(P < 0.05);与剂量配伍4组相比较,剂量配伍2组足肿胀度下降,差异有统计学意义(P < 0.05)。与模型对照组比较,生理盐水组、地塞米松组及各个剂量配伍组MDA含量和NO含量均低于模型对照组组,差异有统计学意义(P < 0.05);与剂量配伍4组进行对比,剂量配伍2组NO含量和MDA的含量均下降,差异有统计学意义(P < 0.05)。结论 三黄泻心汤的不同剂量配伍时抗炎作用不一样。 |
英文摘要: |
Objective: To compare the anti-inflammatory effects of Xiexin Decoction with different doses of compatibility and its anti-inflammatory effects. Methods:Carrageenan was used to induce the inflammation model in mice. The mice were oral administrated with Xiexin Decoction with different doses for 5 days, then the swelling degree of the feet was measured. the content of malondialdehyde (MDA) and Nitric oxide (NO) were determined by the test to investigate the anti-inflammatory activity. Results:Compared with the model control group, the foot swelling degree of saline group, dexamethasone group and dose compatibility groups was significantly lower (P < 0.05), and compared with dose compatibility group 4, the foot swelling degree of dose compatibility group 2 significantly decreased (P<0.05). Compared with the model control group, MDA and NO contents in saline group, dexamethasone group and dose compatibility groups were significantly lower than those in model control group (P < 0.05); compared with the dose compatibility group 4, NO and MDA contents in dose compatibility group 2 were significantly decreased (P < 0.05). Conclusion:The Sanhuang Xiexin Decoctions with different contents have different anti-inflammatory effects. |
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