| 段凯旋,罗文浩,罗琼,王博龙.基于BATMAN-TCM在线分析平台研究钩藤药理机制[J].井冈山大学自然版,2019,40(2):91-96 |
| 基于BATMAN-TCM在线分析平台研究钩藤药理机制 |
| PHARMACOLOGICAL MECHANISM OF HOOKVINE BASED ON THE BATMAN-TCM ANALYSIS PLATFORM ON LINE |
| 投稿时间：2018-11-17 修订日期：2018-12-26 |
| DOI：10.3969/j.issn.1674-8085.2019.02.017 |
| 中文关键词: 钩藤 网络药理学 活性成分 药理作用 作用靶点 |
| 英文关键词: hookvine network pharmacology active ingredients pharmacological effects action target |
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| 中文摘要: |
| 目的 基于BATMAN-TCM在线分析工具研究钩藤主要活性成分及药理机制。方法 从BATMAN-TCM数据库中提取钩藤的化学成分，以Score cutoff ≥ 30和P ≤ 0.05筛选活性成分及作用靶点，分析靶点富集的信号通路与疾病，构建活性成分-靶点-通路-疾病网络，预测钩藤的多维药理机制。结果 获得钩藤碱、毛钩藤碱、卡丹宾碱等23个主要活性成分；以及DRD2（多巴胺受体D2基因）、HTR1A （5-羟色胺受体1A）、HTR1B （5-羟色胺受体1B）、SLC18A2等21个核心靶点；活性成分可关联细胞间隙连接、神经活性配体-受体相互作用、钙信号通路等通路11条；可治疗疼痛、心血管系统和神经系统等相关疾病21种。可进一步验证钩藤"多成分-多靶点-多通路"的作用机制。结论 本研究从网络药理学角度探讨钩藤主要活性成分、相关通路及多种药理作用机制，为进一步探讨其作用机制奠定了基础。 |
| 英文摘要: |
| Objective: To study the main active ingredients and pharmacological mechanism of hookvine from the perspective of network pharmacology.Methods: Chemical constituents of hookvine were extracted from BATMAN-TCM database.Score cutoff ≥ 30 and P ≤ 0.05 were used to screen active constituents and action targets.Signal pathways and diseases of target enrichment were analyzed.Active components-targetpathway-disease network was constructed to predict the multidimensional pharmacological mechanism of hookvine.Results: 23 major active components such as rhynchophylline,irradiata,and kadanbin base were obtained.These components can act on 21 core targets such as DRD2(dopamine receptor D2),HTR1A (serotonin receptor 1A),HTR1B (serotonin receptor 1B),SLC18A2,etc;active ingredients can associat with 11 pathways such as cell gap junction,neuroactive ligand-receptor interaction,and calium signaling pathway;it can treat 21 related diseases such as pain,cardiovascular system and nervous system.The mechanism of "multi-component-multi-target-multi-pathway" of hook-vine can be further verified.Conclusion: In this study,the main active components,related pathways and various pharmacological mechanisms of hookvine were discussed from the perspective of network pharmacology,which laid a foundation for further exploration of its mechanism of action. |
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