| 郭建峰.硝苯地平与拉贝洛尔治疗高龄孕妇妊娠期高血压的疗效对比[J].井冈山大学自然版,2018,(6):96-98 |
| 硝苯地平与拉贝洛尔治疗高龄孕妇妊娠期高血压的疗效对比 |
| THERAPEUTIC EFFECTS OF NIFEDIPINE AND LABETALOL IN THE TREATMENT OF HYPERTENSION IN PREGNANCY AMONG OLDER PREGNANT WOMEN |
| 投稿时间：2018-09-09 修订日期：2018-10-11 |
| DOI：10.3969/j.issn.1674-8085.2018.06.019 |
| 中文关键词: 硝苯地平 拉贝洛尔 高龄妊娠 高血压 |
| 英文关键词: nifedipine labetalol dld age pregnancy hypertension |
| 基金项目: |
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| 中文摘要: |
| 目的 比较硝苯地平与拉贝洛尔对高龄孕妇妊娠高血压病的疗效。方法 选取2017年11月至2018年4月治疗的高龄孕妇妊娠期高血压病患者40例，按照随机数字法分为两组，实验组与对照组均为20例。两组患者按照常规给予硫酸镁解痉、镇痛等治疗，对照组采用硝苯地平控释片降压治疗。试验组采用拉贝洛尔降压治疗。连续用药1周。比较两组收缩压及舒张压变化水平、分娩结局、不良反应发生率。结果 两组患者的收缩压与舒张压较治疗前均有下降（P <0.05），两组比较无统计学意义（P >0.05）；实验组的早产率、新生儿窘迫率、产后出血率均低于对照组，差异有统计学意义（P <0.05）；实验组不良反应发生率低于对照组，差异有统计学意义（χ2=5.03，P <0.05）。结论 硝苯地平与拉贝洛尔均可控制高龄孕妇妊娠高血压病情，但拉贝洛尔更具优势，不良反应较少，安全性更优。 |
| 英文摘要: |
| Objective:To compare the effects of nifedipine and labetalol in the treatment of pregnancy-induced hypertension in older pregnant women. Methods:40 older pregnant women with hypertension from November 2017 to April 2018 were selected and randomly divided into the experimental group and control group (20 cases per group). The patients in two groups were treated with magnesium sulfate for spasmolysis and analgesia according to the conventional methods, Nifedipine controlled-release tablets and labetalol antihypertensive were respectively applied in the control group and experimental group. It lasted 1 week. The systolic blood pressure and diastolic blood pressure, the outcome of delivery, and the incidence of adverse reactions were compared between the two groups. Results:The systolic blood pressure and diastolic blood pressure of both groups decreased compared with those before treatment (P < 0.05), but there was no significant difference between the two groups (P > 0.05). The preterm birth rate, neonatal distress rate, and postpartum hemorrhage rate were lower in the experimental group than those in the control group (P < 0.05); the incidence of adverse reactions in the experimental group was significantly lower than that in the control group (χ2=5.03, P < 0.05). Conclusion:Both nifedipine and labetalol can control pregnancy-induced hypertension in older pregnant women, but labetalol has more advantages, fewer adverse reactions, and better safety. |
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