| 马超,袁文金,吴红云,罗骏,罗辉.不同强度远程缺血预适应对稳定型心绞痛患者运动耐量、血清一氧化氮及内皮素的影响[J].井冈山大学自然版,2018,(4):92-94,99 |
| 不同强度远程缺血预适应对稳定型心绞痛患者运动耐量、血清一氧化氮及内皮素的影响 |
| EFFECTS OF DIFFERENT INTENSITY REMOTE ISCHEMIC PRECONDITIONING ON EXERCISE TOLERANCE, SERUM NITRIC OXIDE AND ENDOTHELIN IN PATIENTS WITH STABLE ANGINA PECTORIS |
| 投稿时间：2018-02-06 修订日期：2018-05-16 |
| DOI：10.3969/j.issn.1674-8085.2018.04.017 |
| 中文关键词: 远程缺血预适应 稳定性心绞痛 运动耐量 一氧化氮 内皮素 |
| 英文关键词: remote ischemic preconditioning stable angina exercise tolerance nitric oxide endothelin |
| 基金项目:赣州市2015年科技指导性计划项目（GZ2015ZSF138） |
| 作者 | 单位 | E-mail | | 马超 | 赣州市人民医院药剂科, 江西, 赣州 341100 | | | 袁文金 | 赣州市人民医院心内科, 江西, 赣州 341100 | | | 吴红云 | . 赣州市人民医院眼科, 江西, 赣州 341100 | | | 罗骏 | 赣州市人民医院心内科, 江西, 赣州 341100 | | | 罗辉 | 井冈山大学医学部, 江西, 吉安 343009 | luohui9898@163.com |
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| 中文摘要: |
| 目的 对比不同强度远程缺血预适应对稳定型心绞痛患者运动耐量、血清一氧化氮及内皮素的影响。方法 将我院2016年1月至2017年6月76例稳定型心绞痛患者随机分为强度I组、Ⅱ组、Ⅲ组、IV组；以上各组均在冠心病标准治疗基础上，采用远程缺血预适应训练仪进行远程缺血预适应训练，其中强度I组一次做3个循环，共30 min；强度Ⅱ组一次做4个循环，共40 min；强度Ⅲ组一次做5个循环，共50 min；强度IV组一次做6个循环，共60 min；以上各组每天上午、下午均各做1次，共持续1周。测定并对比四组患者试验前及试验结束时6 min的步行距离、血清一氧化氮（NO）水平及内皮素水平。结果 （1）6 min的步行距离：较试验前四组均明显改善，试验后Ⅱ组、Ⅲ组及IV组分别平均为：584、611、615 m，与I组比均有明显提高（P<0.05），且IV组提高最明显。（2） NO：四组均较试验前明显提高，试验后Ⅱ组、Ⅲ组及IV组分别平均为：60.23、67.84、68.99 μmol/L，较I组均有明显提高（P<0.05），且Ⅲ和IV组提高最明显，两者无明显差异，（P>0.05）。（3）内皮素：较试验前四组均明显降低，试验后Ⅱ组、Ⅲ组及IV组平均值分别为：30.17、25.59、24.85 pg/mL，与I组比均有明显降低（P<0.05），且Ⅲ和IV组降低最明显，两者无明显差异（P>0.05）。结论 不同强度的远程缺血预适应对稳定型心绞痛患者的作用保护存在差异，且远程缺血预适应强度IV组的保护作用最强。 |
| 英文摘要: |
| Objective: To compare the effects of different intensity of remote ischemic preconditioning on exercise tolerance, serum nitric oxide and endothelin in patients with stable angina. Methods: 76 patients from January 2016 to June 2017 were randomly divided into intensity group I, group Ⅱ, group Ⅲ and group IV.Based on the standard treatment of coronary heart disease, all the above groups used remote ischemic preconditioning training instrument to carry out remote ischemic preconditioning training. Intensity group Ⅱ did 4 cycles at a time for 40 minutes. Intensity group Ⅲ did 5 cycles at a time for 50 minutes. Intensity group IV did 6 cycles at a time for 60 minutes. Each of the above groups did it every morning and afternoon for 1 week. The walking distance, serum nitric oxide (NO) level and endothelin level were measured and compared before and after the test. Results: (1) 6 minutes walking distance:it was obviously improved in four groups after test, the walking distances of group Ⅱ, Ⅲ and IV were 584 m, 611 m and 615 m respectively which were significantly higher than that in group I (P<0.05), the most for group IV. (2) NO:it was improved obviously in four groups after test, and the averages of group Ⅱ, Ⅲ and IV respectively were 60.23 μmol/L, 67.84 μmol/L, 68.99 μmol/L which were significantly higher than that of group I (P<0.05), and the most for group Ⅲ and IV without significant difference between them (P>0.05). (3) Endothelin:it was significantly lower in the four group after test, the averages of group Ⅱ, Ⅲ and IV are 30.17 pg/ml, 25.59 pg/ml, 24.85 pg/ml respectively, which were significantly lower than that in group I (P<0.05), the most for group Ⅲ and IV without significant difference between them (P>0.05). Conclusion: There are differences in the effects of different intensity of remote ischemic preconditioning on patients with stable angina. |
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