| 刘志强,王博龙.基于TCMSP抗肿瘤中药小分子EGFR-TKI的研究[J].井冈山大学自然版,2018,(2):87-92 |
| 基于TCMSP抗肿瘤中药小分子EGFR-TKI的研究 |
| ANTI-TUMOR SMALL MOLECULE EGFR-TKI FROM CHINESE MEDICINE BASED ON TCMSP |
| 投稿时间：2018-01-07 修订日期：2018-02-12 |
| DOI：10.3969/j.issn.1674-8085.2018.02.016 |
| 中文关键词: 中药小分子 肿瘤 表皮生长因子受体 反向分子对接 靶点 |
| 英文关键词: small molecules of traditional Chinese medicine tumor epidermal growth factor receptor reverse molecular docking targets |
| 基金项目:江西省教育厅科技计划项目（GJJ12596） |
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| 中文摘要: |
| 目的 研究分析中药小分子表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKI）的抗肿瘤情况。方法 挖掘中药系统药理学数据库与分析平台（TCMSP）中药小分子表皮生长因子受体抑制剂，利用反向分子对接服务器（DRAR-CPI）进行靶点验证。结果 木犀草素、槲皮素、金雀异黄酮、表没食子儿茶素没食子酸酯、漆黄素5种中药小分子与表皮生长因子受体（EGFR）结合良好。结论 中药小分子EGFR-TKI能从多个靶点、多种途径抑制肿瘤细胞的生长和扩散，利用中药小分子开发新一代多靶点EGFR-TKI具有广阔的前景。 |
| 英文摘要: |
| Objective:To study the status of the anti-tumor small molecule epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) from Chinese medicine. Methods:We collected the Chinese medicine small molecule EGFR-TKI based on traditional Chinese medicine pharmacology system technology platform (TCMSP), and predicted their targets using reverse molecular docking server (DRAR-CPI). Results:Luteolin, quercetin, genistein, epigallocatechin-3-gallate, fisetin could interact with the EGFR well. Conclusion:Chinese medicine small molecule EGFR-TKI could inhibit the growth and proliferation of tumor cell by multiple targets and approaches. It has a broad prospect using traditional Chinese medicine small molecules to develop a new generation of multiple targets EGFR-TKI. |
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