| 何旺龙,黄葵,黄志强,林娥媚.多巴胺修饰聚乙二醇的合成及与Fe3+配位研究[J].井冈山大学自然版,2017,(1):34-39 |
| 多巴胺修饰聚乙二醇的合成及与Fe3+配位研究 |
| SYNTHESIS OF DOPAMINE-MODIFIED POLYETHYLENE GLYCOL COMPLEXED WITH Fe3+ |
| 投稿时间：2016-11-17 修订日期：2016-12-27 |
| DOI：10.3969/j.issn.1674-8085.2017.01.007 |
| 中文关键词: 多巴胺 聚乙二醇 pH调控 Fe3+配位 水凝胶 |
| 英文关键词: dopamine polyethylene glycol pH regulation Fe3+ complexation hydrogels |
| 基金项目:福建省科技厅自然科学基金项目（2013J01055）；国家大学生创新创业训练计划项目（201311311003） |
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| 中文摘要: |
| 利用对硝基苯基氯甲酸酯活化方法合成多巴胺（DOPA）末端修饰的线型聚乙二醇PEG-（DOPA）2，通过核磁共振技术、紫外-可见分光光度法和动态流变学技术对产物结构和性质进行表征。实验结果表明，多巴胺与PEG-10000的偶联率高达98.0%；随着pH值增大（3.5~12），多巴胺基团与金属Fe3+发生从一配位到稳定三配位结构的转变；在一定聚合物浓度下（≥9%（w/v，重量/体积比），多巴胺基团与Fe3+的物质的量比为3：1）和pH=12时，PEG-（DOPA）2与Fe3+发生配位，引起PEG聚合物之间的交联，形成PEG-DOPA-Fe3+水凝胶。该凝胶具有pH敏感性和自愈性等多功能性，在生物医学工程和水下机械涂层材料等领域具有潜在应用。 |
| 英文摘要: |
| Using p-nitrophenyl chloroformate as the activating agent, the synthesis of a dopamine modified linear PEG polymer PEG-(DOPA)2 was studied, the compound is characterized by UV-Vis and NMR spectroscopy as well as Rheology. Experimental results show that PEG -10000 is modified with dopamine groups with highcoupling efficiency of 98.0%; with increase of pH from 3.5 to 12, dopamine groups coordinates with Fe3+ with stoichiometry changing from mono- to tris; at a certain polymer concentration (≥9% (w/v), dopamine: Fe3+=3:1)and pH=12, a solution of PEG-(DOPA)2 could coordinate with Fe3+ and form a PEG-DOPA-Fe3+ hydrogel with multifunctional properties, such as pH sensitive and self-healing ability, having potential uses in biomedical applications as well as underwater adhesives. |
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