| 刘思美,苟中富,张庆.急性肾损伤程度的评估与α1-微球蛋白的相关性研究[J].井冈山大学自然版,2016,(6):96-99 |
| 急性肾损伤程度的评估与α1-微球蛋白的相关性研究 |
| STUDY ON THE RELATIONSHIP BETWEEN THE DEGREE OF AKI AND α1-MG |
| 投稿时间：2016-10-11 修订日期：2016-11-01 |
| DOI：10.3969/j.issn.1674-8085.2016.06.020 |
| 中文关键词: α1-微球蛋白 急性肾损伤 诊断 评估 |
| 英文关键词: α-microglobulin acute kidney injury(AKI) diagnosis assessment |
| 基金项目:国家高技术研究发展计划（国家863计划项目）（2014AA022304） |
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| 中文摘要: |
| 目的 通过探讨α1-微球蛋白与急性肾损伤程度的评估的相关性临床价值，拟验证血α1-微球蛋白用于临床急性肾损伤患者程度的评价。方法 选择2015年7月~2016年6月在我院门诊和住院确诊为急性肾损伤患者73例，设为观察组（按照患者病情不同分为一期48例，二期组11例，三期组14例）。另选择同期在该院进行健康体检者70例设为对照组。所有受试者均进行α1微球蛋白（α-Microglobulin，简称α1-MG）检测，同时检测诊断早期肾损伤指标胱抑素C（cystatin c，简称Cys-C）水平，并对结果进行分析。结果 α1-MG各期组检验结果：一期组（26.2±7.94）mg，二期组（34.25±14.28）mg，三期组（72.58±36.9）mg，对照组（21.46±5.93）mg。随着病情加重，α1-MG水平也逐步升高，观察者与对照组、观察组组间比较，显示差异均有统计学意义（P<0.05 ）；α1-MG的阳性率：一期组12例（25%），二期组8例（72.73%），三期组13例（92.86%），和同期组Cys-C的阳性率比较，差异均显示无统计学意义（P>0.05）。结论 α1-微球蛋白是辅助诊断急性肾损伤的良好指标，可参与评估急性肾损伤程度。 |
| 英文摘要: |
| Objective: To investigate the clinical value of α1-MG for AKI assessment. Methods: 73 cases of patients with AKI were divided into first-stage group, second-stage-group and third-stage group according to their illness. In addition, there was a healthy control group including 70 cases individuals. α1-MG, Cys-C, Cr, Bun of allcases were measured, compared and analyzed. Rsults: The results of α1-MG in each stage:stage 1 group (26.2+7.94) mg, stage 2 group (34.25+14.28) mg, stage 3 group (72.58+36.9) mg, control group (21.46+21.46) mg. As the illness grew worse, α1-MG increased gradually, differences between observation group and control group were statistically significant (P<0.05). The positive rate of α1-MG:stage 1 group 12 (25%), stage 2 group 8 (72.73%), stage 3 group 13 (92.86%), compared with the positive rate of the same set of Cys-C, the differences had no statistical significance (P>0.05). Conclusion: α1-MG is a good indicator for secsecondary diagnosis of AKI, can be used in the assessment of AKI degree. |
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