| 刘兵,郑丽娟,梁生林.爵床煎剂对小鼠镇痛抗炎作用初探[J].井冈山大学自然版,2015,(4):70-74 |
| 爵床煎剂对小鼠镇痛抗炎作用初探 |
| PRELIMINARY STUDY ON THE ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ROSTELLULARIA PROCUMBENS DECOCTION IN MICE |
| 投稿时间：2014-10-16 修订日期：2015-05-05 |
| DOI：10.3969/j.issn.1674-8085.2015.04.013 |
| 中文关键词: 爵床 水煎剂 镇痛 抗炎 |
| 英文关键词: Rostellularia procumbens decoction analgesia anti-inflammation |
| 基金项目:国家科技支撑计划项目子课题项目(2012BAC11B02-6);吉安市科技支撑计划项目(吉市科计字[2014]4号) |
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| 中文摘要: |
| 目的 探讨爵床的镇痛、抗炎作用。方法 采用热板法、扭体法致痛,观察高、中、低剂量爵床水煎剂的镇痛作用;采用耳肿法、足肿法致炎,观察高、中、低剂量爵床水煎剂的抗炎作用。结果 爵床水煎剂高、中、低剂量对热板法所致小鼠痛阈值有明显的提高,与生理盐水对照组比较差异极显著(P < 0.01);爵床水煎剂高、中剂量给药后与自身给药前比较,差异显著(P < 0.01),爵床水煎剂低剂量给药后15、30、60 min与给药前比较差异显著 (P < 0.01);爵床水煎剂高、中、低剂量对醋酸所致扭体反应数均有明显抑制作用,与生理盐水对照组比较差异显著(P < 0.01)。爵床水煎剂高、中、低剂量对二甲苯所致小鼠耳廓肿胀均有明显抑制作用,与生理盐水对照组比较差异显著(P < 0.01,P < 0.05);爵床水煎剂高、中、低剂量对蛋清所致小鼠足跖肿胀均有明显抑制作用,与生理盐水对照组比较差异极显著(P < 0.01)。结论 爵床水煎剂具有一定镇痛、抗炎作用。 |
| 英文摘要: |
| Objective: To investigate the analgesic and anti-inflammatory effects of Rostellularia procumbens in mice. Methods: By using the hot-plate and acetic acid writhing method to induce pain in mice, and observe the analgesic effect of different doses of R. procumbens decoction. By using the ear tumefaction, foot swelling to induce inflammation in mice, and observe the anti-inflammatory effect of different decoction doses. Results: Different doses of R. procumbens decoction could significantly elevate the pain threshold with hot plate method (P < 0.01), comparing with the saline control group. High, medium decoction doses and low-dose for 15, 30, 60 min could significantly elevate the pain threshold with hot plate method (P < 0.01), comparing with the self-administration earlier. Compared with the saline control group, the decoction could significantly reduce the number with acetic acid writhing method, restrain mouse ear tumefaction caused by xylene and mouse foot swelling caused by egg white (P < 0.01). Conclusion: The results shows R. procumbens decoction has the analgesic effects and anti-inflammatory. |
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