| 郑丽娟,余晓珊,梁生林,黄玉双,黄宜财.厚朴皮、叶、花水提物镇痛作用的比较研究[J].井冈山大学自然版,2015,(2):74-77 |
| 厚朴皮、叶、花水提物镇痛作用的比较研究 |
| COMPARATIVE STUDY ON THE ANALGESIC EFFECT OF WATER EXTRACTS OF MAGNOLIA OFFICINALIS BARK, LEAF AND FLOWER |
| 投稿时间：2014-12-09 修订日期：2015-02-12 |
| DOI：10.3969/j.issn.1674-8085.2015.02.015 |
| 中文关键词: 厚朴皮、叶、花 水提物 镇痛 比较 |
| 英文关键词: Magnolia officinalis bark leaf flower water extract analgesia comparision |
| 基金项目:国家科技支撑计划项目子课题项目(2012BAC11B02-6) |
| 作者 | 单位 | E-mail | | 郑丽娟 | 井冈山大学医学院, 江西, 吉安 343009 | | | 余晓珊 | 井冈山大学医学院, 江西, 吉安 343009 | | | 梁生林 | 井冈山大学医学院, 江西, 吉安 343009 | slliang1962@163.com | | 黄玉双 | 井冈山大学医学院, 江西, 吉安 343009 | | | 黄宜财 | 井冈山大学医学院, 江西, 吉安 343009 | |
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| 中文摘要: |
| 目的 探讨并比较厚朴皮、叶、花的镇痛作用。方法 采用热板法、醋酸扭体法致痛,观察高、低剂量厚朴皮、叶、花水提物的镇痛作用。结果 厚朴干皮、根皮、枝皮、叶、花水提物高、低剂量对热板法所致小鼠痛阈值无影响,与蒸馏水对照组和自身给药前比较差异无统计学意义(P > 0.05);厚朴干皮、根皮、枝皮、叶、花水提物高、低剂量对醋酸所致扭体反应数均有明显抑制作用,与蒸馏水对照组比较差异显著(P < 0.01),厚朴根皮、枝皮、叶、花水提物高、低剂量组与厚朴干皮相对应剂量组比较差异无统计学意义(P > 0.05)。结论 厚朴干皮、根皮、枝皮、叶、花水提物均具有镇痛作用,且厚朴根皮、枝皮、叶、花可以代替厚朴干皮用于镇痛。 |
| 英文摘要: |
| Objective: To investigate and compare the analgesic effect of Magnolia officinalis bark, leaf, flower in mice. Methods: Using the hot-plate and acetic acid writhing method to induce pain in mice, to observe the analgesic effect of high and low doses of water extracts of M. officinalis bark, leaf and flower. Results: Water extracts of high and low doses of M. officinalis stem, root and branch bark, leaf, flower had no significant effect on the pain threshold caused by hot plate method compared with the distilled water control group and the data before the drugs administration (P > 0.05), but it is reversed for that by acetic acid writhing method, and there was no significant difference between the treatment of stem and others (P > 0.05). Conclusion: The results showed that water extracts of different part's bark and organs of M. officinalis possessed the analgesic effects, root bark, branch bark and leave could replace stem bark for analgesia. |
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