岳红坤,周冉,王景翔,马珊珊.黄芩苷固体分散体的研制[J].井冈山大学自然版,2013,(2):89-93 |
黄芩苷固体分散体的研制 |
RESEARCH ON BAICALIN SOLID DISPERSION |
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DOI: |
中文关键词: 黄芩苷 固体分散体 溶出度 溶剂法 |
英文关键词: baicalin solid dispersion dissolution rate solvent method |
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中文摘要: |
目的研制黄芩苷固体分散体,并对其进行考察。方法以PEG6000为载体,用溶剂法、熔融法、溶剂.熔融法、研磨法制备黄芩苷固体分散体,并通过紫外、红外、溶解度、溶出度的考察比较不同药物与载体的比例对固体分散体的影响。结果溶剂法即共沉淀法,药物与PEG6000的比例为1:8时的固体分散体最优。结论制备方法和药物与载体的比例都会影响黄芩苷-PEG6000固体分散体的质量。 |
英文摘要: |
Objective : To prepare and investigate baicalin solid dispersion. Methods: Using PEG6000 as cartier, baicalin solid dispersion was prepared by solvent, melting, solvent-melting, grinding methods. The influence on solid dispersion of different proportion was studied by UV, IR, solubility and dissolution rate. Results: The solid dispersions of solvent method and the ratio of the drug and PEG6000 1:8 is the best. Conclusion: The quality of solid dispersion was affected by the preparation method and the ratio. |
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