| 廖艺聪,李艳,王雷,王亚祥,赵冰雪,邓倩,谈艳雯,刘强,严涛,孟晶.小鼠避暗实验三种训练方法的效果比较[J].井冈山大学自然版,2011,(4):101-103 |
| 小鼠避暗实验三种训练方法的效果比较 |
| EFFECT COMPARISON OF THREE KINDS OF STEP TRROUGH TEST'S TRAINING METHODS IN MICE |
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| DOI： |
| 中文关键词: 避暗实验 小鼠 训练方法 氯胺酮 |
| 英文关键词: step through test mice training method ketamine |
| 基金项目:江苏省高校自然科学基础研究项目(08KJD320006) |
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| 中文摘要: |
| 目的对小鼠避暗实验三种常用训练方法的效果进行比较。方法小鼠腹腔注射氯胺酮(25mg·kg-1)建立遗忘模型,分别采用单次适应单次电击(MOS)法,单次适应限时训练(MOL)法,多次适应限时训练(MUL)法训练小鼠并于24h后进行测试,记录步入潜伏期和错误次数。结果与对照组相比,MOS法仅显示步入潜伏期的差异(P<0.05);MOL和MUL法两种学习记忆指标均能显示出差异,而MUL法指标的差异更显著(P<0.01)。结论多次适应限时训练是小鼠避暗实验相对稳定的训练方法。 |
| 英文摘要: |
| Objective：To compare the effects of three kinds of step through test＇s training methods in mice.Methods：Amnestic model was established by intraperitoneal injection of ketamine（25 mg·kg-1）.The mice were trained by mono-adaptation and mono-shock（MOS） method,mono-adaptation and time-limited（MOL） method or multi-adaptation and time-limited（MUL） method,then the step through latency and error times were observed in the testing trial 24 h later.Results：Compared with the control group,the step through latency just indicated difference in MOS method（P 0.05）;both kinds of indication showed significant difference in MOL and MUL methods,the indexes in latter one were more significant（P 0.01）.Conclusion：Multi-adaptation and time-limited method was testified to be relatively dependable for step through test in mice. |
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